Jennifer Aniston on Wednesday slammed Sen. JD Vance (R-Ohio) for past comments on women who don’t have children.

The “Friends” star took aim at Donald Trump’s new running mate for griping to Tucker Carlson in 2021 that the country was run by a “bunch of childless cat ladies who are miserable at their own lives and the choices that they’ve made and so they want to make the rest of the country miserable, too.”

Vance mentioned Vice President Kamala Harris, who is a stepmother to two children with her husband, Doug Emhoff, as one of them. Harris has quickly emerged as the presumptive Democratic nominee after President Joe Biden withdrew from the race.

Aniston took to her Instagram stories to blast the attitude of Vance, an opponent of the Right to IVF Act, toward reproductive rights and choice.

“I can’t believe this is coming from a potential VP of The United States,” wrote the “Morning Show” actor, who rarely makes public comments on politics. “All I can say is ... Mr. Vance, I pray that your daughter is fortunate enough to bear children of her own one day. I hope she will not need to turn to IVF as a second option. Because you are trying to take that away from her, too.”

Vance has a 2-year-old daughter and two sons, aged 4 and 6.

Aniston has shared her IVF and fertility struggles, criticizing tabloid speculation over whether she was pregnant in a 2016 HuffPost essay.

“We are complete with or without a mate, with or without a child,” she wrote. “We get to decide for ourselves what is beautiful when it comes to our bodies.”